Selected Publications

Click here for a full list of publications.

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.

Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ.
Nature. 2020 Dec;588(7839):670-675.

Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells.

Ding S, Song Y, Brulois KF, Pan J, Co JY, Ren L, Feng N, Yasukawa LL, Sánchez-Tacuba L, Wosen JE, Mellins ED, Monack DM, Amieva MR, Kuo CJ, Butcher EC, Greenberg HB.
Gastroenterology. 2020 Jul;159(1):214-226.e1.

Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor.

Perkins A, Tudorica DA, Amieva MR, Remington SJ, Guillemin K.
PLoS Biol. 2019 Aug;17(8):e3000395.

Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.

Wosen JE, Ilstad-Minnihan A, Co JY, Jiang W, Mukhopadhyay D, Fernandez-Becker NQ, Kuo CJ, Amieva MR, Mellins ED.
Front Immunol. 2019;10:1970.

High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach.

Fung C, Tan S, Nakajima M, Skoog EC, Camarillo-Guerrero LF, Klein JA, Lawley TD, Solnick JV, Fukami T, Amieva MR.
PLoS Biol. 2019 May; 17(5): e3000231.

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.

Co JY, Margalef-Catala M, Li X, Mah AT, Kuo CJ, Monack DM, Amieva MR.
Cell Rep. 2019 Feb; 26: 2509-20.

Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication.

Ren L, Ding S, Song Y, Li B, Ramanathan M, Co J, Amieva MR, Khavari PA, Greenberg HB.
J Biol Chem. 2019 Apr; 294: 5993-6006.

A dual-function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells.

Antonoplis A, Zang X, Huttner MA, Chong KKL, Lee YB, Co JY, Amieva MR, Kline KA, Wender PA, Cegelski L.
J Am Chem Soc. 2018 Nov; 140: 16140-51.

A dock-and-lock mechanism clusters ADAM10 at cell-cell junctions to promote α-toxin cytotoxicity.

Shah J, Rouaud F, Guerrera D, Vasileva E, Popov LM, Kelley WL, Rubinstein E, Carette JE, Amieva MR, Citi S.
Cell Rep. 2018 Nov; 25: 2132-47.

The soluble extracellular domain of E-cadherin interferes with EPEC adherence via interaction with the Tir:intimin complex.

Login FH, Jensen HH, Pedersen GA, Amieva MR, Nejsum LN.
FASEB J. 2018 Jun; doi: 10.1096/fj.201800651.

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.
Nat Chem Biol. 2018 May; 14: 609-17.

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF.
Nature. 2017 Aug; 548(7668): 451-5.

The basolateral vesicle sorting machinery and basolateral proteins are recruited to the site of enteropathogenic E. coli microcolony growth at the apical membrane.

Pedersen GA, Jensen HH, Schelde AB, Toft C, Pedersen HN, Ulrichsen M, Login FH, Amieva MR, Nejsum LN.
PLoS One. 2017 Jun; 12(6): e0179122.

Multiple acid sensors control Helicobacter pylori colonization of the stomach.

Huang JY, Sweeney EG, Guillemin K, Amieva MR.
PLoS Pathog. 2017 Jan; 13(1): e1006118.

Pathobiology of Helicobacter pylori-induced gastric cancer.

Amieva MR, Peek RM Jr.
Gastroenterology. 2016 Jan; 150(1): 64-78.

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.

Popov LM, Marceau CD, Starkl PM, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE*, Amieva MR*.
Proc Natl Acad Sci USA. 2015 Nov; 112(46): 14337-42.
*Co-senior authors.

Quantitative Imaging of Gut Microbiota Spatial Organization.

Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL.
Cell Host Microbe. 2015 Oct; 18(4): 478-88.

Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium.

Huang JY, Sweeney EG, Sigal M, Zhang HC, Remington SJ, Cantrell MA, Kuo CJ, Guillemin K, Amieva MR.
Cell Host Microbe. 2015 Aug; 18(2): 147-56.

Helicobacter pylori CheZHP and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor.

Lertsethtakarn P, Howitt MR, Castellon J, Amieva MR, Ottemann KM.
Mol Microbiol. 2015 Sept; 97(6): 1063-78.

Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands.

Sigal M, Rothenberg ME, Logan CY, Lee JY, Honaker RW, Cooper RL, Passarelli B, Camorlinga M, Bouley DM, Alvarez G, Nusse R, Torres J, Amieva MR.
Gastroenterology. 2015 Jun; 148(7): 1392-1404.

Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency.

Noto JM, Lee JY, Gaddy JA, Amieva MR, Peek RM Jr.
J Infect Dis. 2014 Jun; 211(11): 1790-4.

Three-Dimensional Human Skin Models to Understand Staphylococcus aureus Skin Colonization and Infection.

Popov L, Kovalski J, Grandi G, Bagnoli F, Amieva MR.
Front Immunol. 2014 Feb; 5: 41.

Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans.

Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM Jr.
J Clin Invest. 2013 Jan; 123(1):479-92.

ChePep controls Helicobacter pylori infection of the gastric glands and chemotaxis in the Epsilonproteobacteria.

Howitt MR, Lee JY, Lertsethtakarn P, Vogelmann R, Joubert LM, Ottemann KM, Amieva MR.
MBio. 2011 Jul; 2(4).

Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface.

Tan S, Noto JM, Romero-Gallo J, Peek RM Jr, Amieva MR.
PLoS Pathog. 2011 May; 7(5):e1002050.

Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.

Arnold IC, Lee JY, Amieva MR, Roers A, Flavell RA, Sparwasser T, Müller A.
Gastroenterology. 2011 Jan; 140(1):199-209.

Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion.

Pentecost M, Kumaran J, Ghosh P, Amieva MR.
PLoS Pathog. 2010 May; 6(5):e1000900.

Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche.

Tan S, Tompkins LS, Amieva MR.
PLoS Pathog. 2009 May; 5(5):e1000407.

Host-bacterial interactions in Helicobacter pylori infection.

Amieva MR, El-Omar EM.
Gastroenterology. 2008 Jan; 134(1):306-23.

The role of bacterial pathogens in cancer.

Vogelmann R, Amieva MR.
Curr Opin Microbiol. 2007 Feb; 10(1):76-81.

Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion.

Pentecost M, Otto G, Theriot JA, Amieva MR.
PLoS Pathog. 2006 Jan; 2(1):e3.

Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells.

Bagnoli F, Buti L, Tompkins L, Covacci A, Amieva MR.
Proc Natl Acad Sci USA. 2005 Nov; 102(45):16339-44.

Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection?

Mueller A, Falkow S, Amieva MR.
Cancer Epidemiol Biomarkers Prev. 2005 Aug; 14(8):1859-64.

Breaking into the epithelial apical-junctional complex—news from pathogen hackers.

Vogelmann R*, Amieva MR*, Falkow S, Nelson WJ.
Curr Opin Cell Biol. 2004 Feb; 16(1):86-93.
*Co-first authors

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.

Amieva MR*, Vogelmann R*, Covacci A, Tompkins LS, Nelson WJ, Falkow S.
Science. 2003 May; 300(5624):1430-4.
*Co-first authors

Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells.

Amieva MR, Salama NR, Tompkins LS, Falkow S.
Cell Microbiol. 2002 Oct;4(10):677-90.