Current News



H. pylori rapidly swims away from the tip of a microinjection needle that is releasing hydrochloric acid.

Publication of PLoS Pathogens article on the role of acid sensing in Helicobacter pylori stomach colonization

January 2017

Congratulations to Julie, the lab, and her collaborators for getting her manuscript published in PLoS Pathogens, and for the article getting highlighted on the front page of the journal website! In this work, Julie investigated how Helicobacter pylori sensing of acid gradients enable it to colonize and survive in the stomach, and also how acid sensing controls the interaction of the bacteria with the gastric epithelium.

Link to article

Press coverage of Julie's work
Stomach bugs' bad acid trip: Scientists find tools H. pylori uses to sense organ's wicked secretions

Conferences and research presentations on this work
*Sensory Transduction in Microorganisms Gordon Research Seminar 2016 (Talk & Poster)
*Sensory Transduction in Microorganisms Gordon Research Conference 2016 (Poster)



Dr. Lauren celebrating after her defense!

Lauren successfully defends her thesis!

March 2016

Lauren successfully defends her thesis, "The adherens junctions control susceptibility to Staphylococcus aureus α-toxin". Congratulations, Dr. Popov!!!













Dr. Julie celebrating after her defense!

Julie successfully defends her thesis!

February 2016

Julie successfully defends her thesis, "Chemodetection and response to host signals facilitate Helicobacter pylori colonization of the gastric epithelium". Congratulations, Dr. Huang!!!











Adherens junction protein PLEKHA7 (green) in human lung epithelial cells. White = actin, Blue = nuclei.

Time-lapse visualization of lesion development and repair in WT and PLEKHA7 KO mice following MRSA skin infection. Mice that lack PLEKHA7 resolve MRSA skin infection with significantly less tissue loss compared to WT animals.

Publication of PNAS article on Staphylococcus aureus α-toxin and the cellular adherens junctions

October 2015

Congratulations to Lauren, the lab, and her collaborators for getting her manuscript published in PNAS! In this work, Lauren and her collaborators conducted a haploid genetic screen to look for host factors important for Staphylococcus aureus α-toxin virulence. They discovered that components of the host cellular adherens junctions control susceptibility to this important virulence factor. In this study, Lauren focused on the role of the adherens junction protein PLEKHA7 during α-toxin injury and Staphylococcus aureus infections.

Link to article

Press coverage of Lauren's work
Inside job: Staphylococcus aureus gets critical assist from host-cell protein accomplice
Staphylococcus aureus Achilles' heel
Scientists discover weak spot of the superbug MRSA

Journal articles highlighting Lauren's work
In this issue by PNAS
The ever-emerging complexity of α-toxin's interaction with host cells

Lauren's article got recommended on F1000 prime!
F1000 Prime Article Recommendation by Dr. Drusilla L. Burns

Conferences and research presentations on this work
*Stanford Microbiology & Immunology Department Noon Seminar 2014 (Talk)
*Stanford Microbiology & Immunology Department Retreat 2014 (Talk)
*Keystone Conference on Innate Immunity and Determinants of Microbial Pathogenesis 2015 (Poster)
*Stanford Pediatrics Department Retreat 2015 (Talk): Lauren was awarded a prize for best talk!
*Gordon Research Seminar on Staphylococcal Diseases 2015 (Talk)
*Gordon Research Conference on Staphylococcal Diseases 2015 (Talk): Lauren was one of few students selected to give an oral presentation at the conference!
*Cold Spring Harbor Laboratory Microbial Pathogenesis and Host Response Meeting 2015 (Talk)
*Stanford Bug Club Seminar 2015 (Talk)



H. pylori is attracted to the tip of a microinjection needle that is releasing media that has been conditioned on epithelial cells.


Publication of Cell Host Microbe article on how Helicobacter pylori senses and locates the gastric epithelium

August 2015

Congratulations to Julie, the lab, and her collaborators for getting her manuscript published in the August 2015 issue of Cell Host Microbe! In this work, Julie investigated how Helicobacter pylori senses urea emanating from host cells as a chemoattractant to find its epithelial niche. Make sure to check out the videos Julie recorded of the bacteria's swimming responses to the chemoattractant!

Link to article

Press coverage of Julie's work
When bacteria swarm: H. pylori home in on our stomach cells

Journal articles highlighting Julie's work
H. pylori GPS: Modulating Host Metabolites for Location Sensing
Helicobacter pylori: Lessons in bacterial attraction
Stomach microbe finds a safe haven

Conferences and research presentations on this work
*Stanford Microbiology & Immunology Department Noon Seminar 2012 (Talk)
*Stanford Microbiology & Immunology Department Retreat 2013 (Talk)
*Bay Area Microbial Pathogenesis Symposium 2014 (Talk)
*Microbial Stress Response Gordon Research Seminar 2014 (Talk & Poster)
*Microbial Stress Response Gordon Research Conference 2014 (Poster)
*5th ASM Conference on Beneficial Microbes 2014 (Talk)
*Genentech Infectious Diseases Department Seminar 2015 (Talk)
*Stanford Bug Club Seminar 2015 (Talk)




Publication of Gastroenterology article on how Helicobacter pylori colonizes and manipulates the progenitor and stem cell compartments in the gastric glands

June 2015

Congratulations to Michael, the lab, and his collaborators for getting his manuscript published in Gastroenterology and for getting the cover of the June 2015 issue! In this work, Michael characterized H. pylori interactions with gastric epithelial progenitor and stem cells and how these interactions contribute to host pathology.

Link to article

Press coverage of Michael's work
Ulcer-causing bacteria induces stomach stem cell growth in mice, researchers find
Ulcer-causing bacteria manipulate stomach stem cells to their own ends
Science Update Podcast: Bacteria & Stomach Cancer

Conferences and research presentations on this work
*Stanford Microbiology & Immunology Department Noon Seminar 2014 (Talk)
*Stanford Pediatrics Department Retreat 2014 (Talk): Michael was awarded a prize for best talk!
*United European Gastroenterology Conference 2015 (Talk): Michael was a Top Abstract Prize Awardee!
*Digestive Disease Week 2015 (Talk)